Division Head, Chemistry
I was raised and educated in BC including completion of my MD and Medical Biochemistry residency training. I have worked at St. Paul's Hospital since 2009 and have enjoyed working in this patient focused chemistry lab where I spend 70% of my time, as well as at Vancouver General Hospital where I have a weekly clinic treating adult patients with inborn errors of metabolism. Finally, I am an educator directing the UBC Medical Biochemistry Residency Training Program and chairing the Royal College National Specialty Committee.
More recently, I have taken my interest in addressing the climate crisis on a personal level into my work as a medical biochemist. I am promoting a seismic shift in our medical model of care such that decisions on support for medical programs, and particularly for those contingent on laboratory testing, are reviewed from a quadruple bottom line: a) QALY (in current generation), b) Safety (in current generation), c) Resource cost to current and future generations (in a limited resource planet in which we live), d) and pollution cost (in a planet tipping over pollution boundaries that will irrevocably change health care options for future generations).
- Medical Biochemistry Residency Training Program, UBC 1998 – 2003
- MD, Medicine, University of British Columbia. 1993-1997
Awards and Recognition
The UBC Dept of Pathology & Laboratory Medicine
COMMUNITY ENGAGEMENT and PHILANTHROPY AWARD 2023
Macrocytosis in Mitochondrial DNA Deletion Syndromes.
Almarzooqi F, Vallance H, Mezei M, Lehman A, Horvath G, Rakic B, Zypchen L, Mattman A. Acta Haematol. 2023;146(3):220-225. doi: 10.1159/000529311. Epub 2023 Feb 10.PMID: 36774923 Review.
Functional Localization of Adult-Onset Idiopathic Nesidioblastosis.
Hercus JC, Pasha P, Al Lawati S, Kim P, Mattman A, Webber D, Thompson DM.Case Rep Endocrinol. 2022 Oct 7;2022:2802975. doi: 10.1155/2022/2802975. eCollection 2022.PMID: 36248221
Meter bias correction is a remedy for inter-meter differences in hypoglycemia recognition rates.
Mattman A, Vallance H, Kaur S, Burton T, Fung A.Paediatr Child Health. 2022 Jul 1;27(6):382-383. doi: 10.1093/pch/pxac037. eCollection 2022 Oct.PMID: 36200105
Quantitation of IgG Subclasses in Serum Using Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS).
van der Gugten JG, Holmes DT, Mattman A. Methods Mol Biol. 2022;2546:205-216. doi: 10.1007/978-1-0716-2565-1_19.PMID: 36127591
Carnitine deficiency, hearing loss and hydrochlorothiazide-induced diabetes mellitus associated with the recurrent p.Trp85Arg variant in HNF4A.
Mattman A, Masoudi R, Stockler-Ipsiroglu S, Zivkovic I, Lehman A, Dionne JM.Am J Med Genet A. 2022 Oct;188(10):3139-3141. doi: 10.1002/ajmg.a.62927. Epub 2022 Jul 31.PMID: 35909316 No abstract available.
The impact of IgG subclass deficiency on the risk of mortality in hospitalized patients with COPD.
Lee H, Kovacs C, Mattman A, Hollander Z, Chen V, Ng R, Leung JM, Sin DD.Respir Res. 2022 May 31;23(1):141. doi: 10.1186/s12931-022-02052-3.PMID: 35641962 Free PMC article.
Clinical interpretation of serum hepcidin-25 in inflammation and renal dysfunction.
Chen MX, Kuehne N, Mattman A, Liu J, Van der Gugten G, Wright B.J Mass Spectrom Adv Clin Lab. 2022 Mar 28;24:43-49. doi: 10.1016/j.jmsacl.2022.03.002. eCollection 2022 Apr.PMID: 35403094 Free PMC article.
Ketogenic diet for mitochondrial disease: potential role in treating the Multiple Symmetric Lipomatosis phenotype associated with the common MT-TK genetic mutation.
Mattman A, Nadeau E, Mezei MM, Cresswell M, Zhao S, Bosdet T, Sin DD, Guenette JA, Dupuis I, Allin E, Clarke DC.Orphanet J Rare Dis. 2022 Jan 10;17(1):12. doi: 10.1186/s13023-021-02164-x.PMID: 35012599
Intrapartum Fetal Scalp Lactate Testing: Considerations for Implementation and Clinical Decision Making.
Fung AWS, Mattman A, Wang L, Burton T, Beach LA, Füzéry AK; Canadian Society of Clinical Chemists (CSCC) Point of Care Testing Interest Group.J Obstet Gynaecol Can. 2021 Nov;43(11):1244-1246. doi: 10.1016/j.jogc.2021.06.006.PMID: 34758905
Is the diagnostic rate for the common subtypes of A1AT deficiency consistent across two Canadian Provinces?
Estey MP, Tahooni T, Nelson TN, Parker ML, Agbor TA, Yang HM, Jen R, Barakauskas VE, Lam GY, Matthews A, Mattman A.Clin Biochem. 2021 Sep;95:84-88. doi: 10.1016/j.clinbiochem.2021.05.002. Epub 2021 May 6.PMID: 33964271
IgG Levels and Mortality in Chronic Obstructive Pulmonary Disease.
Alotaibi NM, Filho FSL, Mattman A, Hollander Z, Chen V, Ng R, Leung JM, Sin DD.Am J Respir Crit Care Med. 2021 Aug 1;204(3):362-365. doi: 10.1164/rccm.202102-0382LE.PMID: 33945775 No abstract available.
Polyclonal hypergammaglobulinaemia: assessment, clinical interpretation, and management.
Zhao EJ, Cheng CV, Mattman A, Chen LYC.Lancet Haematol. 2021 May;8(5):e365-e375. doi: 10.1016/S2352-3026(21)00056-9.PMID: 33894171 Review.
Maternal vitamin B12 status in early pregnancy and its association with birth outcomes in Canadian mother-newborn Dyads.
Tan A, Sinclair G, Mattman A, Vallance HD, Lamers Y.Br J Nutr. 2021 Dec 28;126(12):1823-1831. doi: 10.1017/S0007114521000581. Epub 2021 Feb 19.PMID: 33602347
Falsely elevated serum estradiol due to heterophile antibody interference: a case report.
Atkins P, Mattman A, Thompson D.Arch Endocrinol Metab. 2021 Nov 1;65(2):237-241. doi: 10.20945/2359-3997000000324. Epub 2021 Feb 15.PMID: 33587834 Free PMC article.
Incidental alpha-1-antitrypsin deficiency found in post-transplant liver allografts: Report of two cases.
Lee J, Yoshida EM, Mattman A, Marquez V, Bukhari H, Farnell D, Yang HM.Hepatol Forum. 2021 Jan 8;2(1):31-33. doi: 10.14744/hf.2020.2020.0013. eCollection 2021 Jan.PMID: 35782889 Free PMC article.
Lactate and glucose as additional considerations to the plasma sodium level-corrected erythrocyte mean corpuscular volume report when using the Sysmex XE-2100.
Zhan SH, Nicolson H, Takahashi A, Mattman A.Clin Chim Acta. 2021 Mar;514:96-99. doi: 10.1016/j.cca.2020.12.016. Epub 2021 Jan 7.PMID: 33359494
Method Limitations in LC-MS/MS and Immunonephelometric Measurement of IgG Subclasses.
van der Gugten G, Mattman A, Ritchie G, Chen LYC, Chin A, Holmes DT, Mills JR, Rao LV.Clin Chem. 2021 Jan 30;67(2):440-441. doi: 10.1093/clinchem/hvaa303.PMID: 33331942 No abstract available.
I have been co-investigator for a number of research projects involved with inborn errors of metabolism, including mitochondrial disease, alpha 1 antitrypsin deficiency, and IgG4 related disease.
Current Projects In My Lab Include
Reviewing the climate implications of doubling the screening rate for type 2 gestational diabetes mellitus by following the Canadian Diabetes Association protocol for the alternative option, as opposed to the preferred option.
I have been the medical biochemistry residency training program director since between 2004 and 2015 and now have returned for an additional term as program director.
In June 2023, I completed a 7 year term as the chair for the Royal College national subspecialty committee for medical biochemistry.
Department of Pathology and Laboratory Medicine
St. Paul's Hospital, 1081 Burrard St.
Vancouver, BC V6Z 1Y6