Andre Mattman

Medical Biochemist
Division Head, Chemistry


I was raised and educated in BC including completion of my MD and Medical Biochemistry residency training. I have worked at St. Paul's Hospital since 2009 and have enjoyed working in this patient focused chemistry lab where I spend 70% of my time, as well as at Vancouver General Hospital where I have a weekly clinic treating adult patients with inborn errors of metabolism. I was selected as the BCALP Chair of the Chemistry science section till 2019.

Academic Background

  • MD, UBC 1997
  • Medical Biochemistry, UBC 2003

Expertise / Research Interests

I have been co-investigator for a number of research projects involved with inborn errors of metabolism, including mitochondrial disease, alpha 1 antitrypsin deficiency, and IgG4 related disease.

Teaching Interests

I have been the medical biochemistry residency training program director since 2004 and have finished my term as of 2015. I am also the vice chair for the national specialty committee.

Selected Publications

  • Patrick DM, Complex Chronic Disease Study Group. Lyme Disease Diagnosed by Alternative Methods: A Phenotype Similar to That of Chronic Fatigue Syndrome. Clin Infect Dis. 2015 Oct 1;61(7):1084-91. doi: 10.1093/cid/civ470. Epub 2015 Jun 16. PubMed PMID: 26082507.
  • Miller RR, Reid WD, Mattman A, Yamabayashi C, Steiner T, Parker S, Gardy J, Tang P, Patrick DM. Submaximal exercise testing with near-infrared spectroscopy in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome patients compared to healthy controls: a case-control study. J Transl Med. 2015 May 20;13:159. doi: 10.1186/s12967-015-0527-8. PubMed PMID: 25990639; PubMed Central PMCID:PMC4438583.
  • Wong SL, Harrison R, Mattman A, Hsiung GY. Nitrous Oxide (N2O)-Induced Acute Psychosis. Can J Neurol Sci. 2014 Sep;41(5):672-4. doi: 10.1017/cjn.2014.30. PubMed PMID: 25373825.
  • Mattman A, Wong S, Urquhart N, Wong P. Total IgG method insensitivity to the presence of IgG4 immunoglobulins. Clin Biochem. 2014 Aug;47(12):1124-7. doi: 10.1016/j.clinbiochem.2014.03.018. Epub 2014 Apr 6. PubMed PMID: 24717727.
  • Webster GM, Venners SA, Mattman A, Martin JW. Associations between perfluoroalkyl acids (PFASs) and maternal thyroid hormones in early pregnancy: a population-based cohort study. Environ Res. 2014 Aug;133:338-47. doi: 10.1016/j.envres.2014.06.012. Epub 2014 Jul 12. PubMed PMID: 25019470.
  • Urquhart N, Mattman A. Corroboration of the prozone phenomenon in IgG4-related disease: comment on the article by Khosroshahi et al. Arthritis Rheumatol. 2014 Jul;66(7):1963-4. doi: 10.1002/art.38663. PubMed PMID: 24729443.
  • Leung JM, Liu JC, Mtambo A, Ngan D, Nashta N, Guillemi S, Harris M, Lima VD, Mattman A, Shaipanich T, Raju R, Hague C, Leipsic JA, Sin DD, Montaner JS, Man SF. The determinants of poor respiratory health status in adults living with human immunodeficiency virus infection. AIDS Patient Care STDS. 2014 May;28(5):240-7. doi: 10.1089/apc.2013.0373. Epub 2014 Apr 17. PubMed PMID: 24742270.
  • Wong SL, Webster GM, Venners S, Mattman A. Second trimester thyroid-stimulating hormone, total and free thyroxine reference intervals for the Beckman Coulter Access® 2 platform. Clin Chim Acta. 2014 Jan 20;428:96-8. doi: 10.1016/j.cca.2013.11.006. Epub 2013 Nov 16. PubMed PMID: 24252656.
  • Hannah-Shmouni F, Sirrs S, Mezei MM, Waters PJ, Mattman A. Increased Prevalence of Hypertension in Young Adults with High Heteroplasmy Levels of the MELAS m.3243A>G Mutation. JIMD Rep. 2014;12:17-23. doi: 10.1007/8904_2013_239. Epub 2013 Jul 12. PubMed PMID: 23846908; PubMed Central PMCID: PMC3897796.
  • Parikh S, Goldstein A, Koenig MK, Scaglia F, Enns GM, Saneto R; Mitochondrial Medicine Society Clinical Directors Working Group; MMS Clinical Director's Work Group, Anselm I, Collins A, Cohen BH, DeBrosse SD, Dimmock D, Falk MJ, Ganesh J, Greene C, Gropman AL, Haas R, Kahler SG, Kamholz J, Kendall F, Korson MS, Mattman A, Milone M, Niyazov D, Pearl PL, Reimschisel T, Salvarinova-Zivkovic R, Sims K, Tarnopolsky M, Tsao CY, van Hove J, Walsh L, Wolfe LA. Practice patterns of mitochondrial disease physicians in North America. Part 1: diagnostic and clinical challenges. Mitochondrion. 2014 Jan;14(1):26-33. doi: 10.1016/j.mito.2013.07.116. Epub 2013 Jul 26. PubMed PMID: 23891656.


Department of Pathology and Laboratory Medicine
St. Paul's Hospital, 1081 Burrard St.
Vancouver, BC V6Z 1Y6