Estimating reference intervals for laboratory tests

December 4, 2018

The Hoffmann indirect reference interval method is more often implemented incorrectly than correctly.  Dr. Dan Holmes and his colleague Dr. Kevin Buhr from the University of Wisconsin review modern alternatives to estimating reference intervals for laboratory tests.

Holmes DT, Buhr KA.  Widespread incorrect implementation of the Hoffman method, the correct approach, and modern alternatives.  Am J Clin Pathol. Published 26 November 2018.